Dear Readers, Welcome to Bio Informatics Objective Questions and Answers have been designed specially to get you acquainted with the nature of questions you may encounter during your Job interview for the subject of Bio Informatics Multiple choice Questions. These Objective type Bio Informatics are very important for campus placement test and job interviews. As per my experience good interviewers hardly plan to ask any particular question during your Job interview and these model questions are asked in the online technical test and interview of many IT & Non IT Industry.
A. Richard Durbin
B. Dayhoff
C. Michael j.Dunn
D. Pearson
Ans: B
A. 1985
B. 1986
C. 1987
D. 1988
Ans: C
A. PROSPECT
B. EMBOSS
C. RASMOL
D. BLAST
Ans: D
A. COPIA
B. patternhunter
C. PROSPECT
D. BLAST
Ans: A
A. 1991
B. 1992
C. 1993
D. 1994
Ans: C
A. DNA finingerprinting
B. DNA polymerase
C. DNA probes
D. DNA microarrays
Ans: D
A. 2 billion base pairs
B. 3 billion base pairs
C. 4 billion base pairs
D. 5 billion base pairs
Ans: B
A. Genomics
B. Cheminformatics
C. Pharmagenomics
D. Phrmacogenetics
Ans: C
A. Bioinformatics
B. Genomics
C. Proteomics
D. Pharmacogenomics
Ans: B
A. Genomics
B. Cheminformatics
C. Proteomics
D. Bioinformatics
Ans: D
a. creating a genomic library
b. sequencing the gene responsible for the disorder
c. developing physical maps from genomic clones
d. determining which environmental factors influence the expression of your gene of interest annotating the gene sequence
Ans: D
A. The location of the clone being sequenced is known relative to other clones within the genomic library in shotgun cloning.
B. Genetic markers are used to identify clones in shotgun cloning.
C. Computer software assembles the clones in the clone-by-clone method.
D. The entire genome is sequenced in the clone-by-clone method, but not in shotgun sequencing.
E. No genetic or physical maps of the genome are needed to begin shotgun cloning.
Ans: E
a. identify open reading frames
b. differentiate between eukaryotic and prokaryotic DNA sequences
c. find regulatory sequences
d. look for DNA-binding domains
e. identify a gene’s function
Ans: A
a. the gene density decreases
b. the number of introns increases
c. the gene size increases
d. an increase in the number of chromosomes
e. repetitive sequences are present
Ans: D
a. If one gene copy is nonfunctional, a backup is available.
b. Larger genomes are more resistant to spontaneous mutations.
c. Duplicated genes will make more of the protein product.
d. Gene duplication will lead to new species evolution.
Ans: A
A. gene duplication
B. alternative splicing mechanisms
C. the formation of polyproteins
D. the formation of nonspecific B cells
E. recombination, deletions, and random assortment of DNA segments
Ans: E
A. separate DNA fragments
B. separate RNA fragments
C. separate different proteins
D. observe a protein in two dimensions
E. separate DNA from RNA
Ans: C
a. gene duplication
b. gene duplication and mutation events
c. mutation events
d. unequal crossing over
e. evolutionary pressure
Ans: B
A. find out whether a certain protein has any role in human disease.
B. search for the genes that are located on the same chromosome as a gene whose sequence you have.
C. find which section of a piece of DNA is transcribed into mRNA.
D. determine the identity of a protein.
Ans: D
A. he's found 3 proteins in the database that have the same sequence as his protein.
B. the chance that these similarities arose due to chance is one in 10^3.
C. there would be 3 matches that good in a database of this size by chance alone.
D. the match in amino acid sequencs is perfect, except for the amino acids at 3 positions.
Ans: C
A. a section of a eukaryotic gene that is translated into protein.
B. a section of a eukaryotic gene that is NOT translated into protein.
C. a regulatory sequence that turns genes on and off.
D. DNA that has no genetic role, but does maintain the physical structure of a chromosome.
Ans: A
A. translate a DNA segment into protein.
B. find out structural and functional information about a protein he's identified.
C. determine how many harmful mutations have been reported in a certain gene.
D. identify an amino acid sequence.
Ans: B
A. Determine what genes are around 'your' protein's gene on its chromosome.
B. Identify a DNA sequence and see if it came from a human.
C. Look up papers about diseases caused by abnormalities in a certain protein.
D. Look at colorful, rotating, 3-D pictures of the tertiary structure of a protein.
Ans: A
A. is only present in vertebrates closely related to humans.
B. replicates by synthesizing an mRNA that then acts as a DNA polymerase.
C. contains over 50% of the genes in the human genome.
D. mutates rapidly and allows us to study evolution over short time scales.
Ans: D
A. File
B. Field
C. Record
D. Data set
Ans: B
A. EMBL
B. SWISS PROT
C. PROSITE
D. TREMBL
Ans: A
A. A collection of hardware components
B. A collection of input-output devices
C. A collection of software routines
D. All of the above
Ans: C
A. OMIM
B. HGMD
C. Golden path
D. GeneCards
Ans: C
A. DNA sequencing
B. Amino acid sequencing
C. DNA bar coding
D. Bioinformatics
Ans: D
A. Portable data
B. Swiss Bank data
C. Sequence data bank
D. Sequence sequence data
Ans: C
A. Multiple sequence alignment
B. Pair wise sequence alignment
C. Phylogenetic analysis
D. All of the above
Ans: B
A. Dendrogram
B. Gene Bank
C. Data retrieving tool
D. Data search tool
Ans: A
A. detection of genes from genome sequence
B. detection of tRNA genes
C. prediction of function of a new gene
D. Identification of functional domains/motifs of proteins
Ans: D
A. J D Watson
B. Margaret Dayhoff
C. Pauline Hogeweg
D. Frederic Sanger
Ans: C
a) SWISS PROT
b) PDB
c) Atlas of protein sequence and structure
d) Protein sequence databank
Ans: C
a) flowchart
b) sequential design
c) procedure
d) algorithm
Ans: D
a) M 13 phage
b) T 4 phage
c) f X174
d) lambda phage
Ans:C
a) dry lab
b) web lab
c) invitro
d) insilico
Ans:D
a) dry lab
b) web lab
c) wet lab
d) insilico
Ans:C
a) dry lab
b) web lab
c) wet lab
d) insilico
Ans:A
a) dry lab
b) web lab
c) wet lab
d) insilico
Ans:B
a) within the glass
b) within the lab
c) outside the lab
d) outside the glass
Ans:A
a) data storage and management
b) drug designing
c) understand relationships between organisms
d) all of the above
Ans:D
a) molecular matching
b) molecular docking
c) molecular fitting
d) molecule affinity checking
Ans:B
a) set of proteins
b) set of proteins in a specific region of the cell
c) entire set of expressed proteins in a cell
d) none of these
Ans:C
a) gene tracing
b) genome mapping
c) genome walking
d) chromosome walking
Ans:B
a) lead
b) find
c) fit drug
d) fit compound
Ans: A